Notch: a membrane-bound transcription factor
نویسندگان
چکیده
منابع مشابه
A membrane-bound NAC transcription factor regulates cell division in Arabidopsis.
Controlled release of membrane-tethered, dormant precursors is an intriguing activation mechanism that regulates diverse cellular functions in eukaryotes. An exquisite example is the proteolytic activation of membrane-bound transcription factors. The proteolytic cleavage liberates active transcription factors from the membranes that can enter the nucleus and evokes rapid transcriptional respons...
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Processing of integral membrane proteins in order to liberate active proteins is of exquisite cellular importance. Examples are the processing events that govern sterol regulation, Notch signaling, the unfolded protein response, and APP fragmentation linked to Alzheimer's disease. In these cases, the proteins are thought to be processed by regulated intramembrane proteolysis, involving site-spe...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2002
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.115.6.1095